AurkA nuclear localization is promoted by TPX2 and counteracted by protein degradation

This study shows that TPX2 co-overexpression in non-transformed human cells induces AurkA nuclear accumulation and promotes its non-mitotic oncogenic functions. The AurkA kinase is a well-known mitotic regulator, frequently overexpressed in tumors. The microtubule-binding protein TPX2 controls AurkA...

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Auteurs principaux:	Italia Anna Asteriti, Federica Polverino, Venturina Stagni, Valentina Sterbini, Camilla Ascanelli, Francesco Davide Naso, Anna Mastrangelo, Alessandro Rosa, Alessandro Paiardini, Catherine Lindon, Giulia Guarguaglini
Format:	Artigo
Langue:	Inglês
Publié:	Life Science Alliance LLC 2023-05-01
Collection:	Life Science Alliance
Accès en ligne:	https://www.life-science-alliance.org/lookup/doi/10.26508/lsa.202201726
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