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Asymmetric Centriole Numbers at Spindle Poles Cause Chromosome Missegregation in Cancer

Chromosomal instability is a hallmark of cancer and correlates with the presence of extra centrosomes, which originate from centriole overduplication. Overduplicated centrioles lead to the formation of centriole rosettes, which mature into supernumerary centrosomes in the subsequent cell cycle. Whil...

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Autori principali: Marco R. Cosenza, Anna Cazzola, Annik Rossberg, Nicole L. Schieber, Gleb Konotop, Elena Bausch, Alla Slynko, Tim Holland-Letz, Marc S. Raab, Taronish Dubash, Hanno Glimm, Sven Poppelreuther, Christel Herold-Mende, Yannick Schwab, Alwin Krämer
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier 2017-08-01
Serie:Cell Reports
Soggetti:
chromosomal instability
centriole
centrosome
PLK4
STIL
mitosis
cancer
microtubule
merotely
chromosome missegregation
Accesso online:http://www.sciencedirect.com/science/article/pii/S2211124717310768
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