USP7 promotes temozolomide resistance by stabilizing MGMT in glioblastoma

Abstract Glioblastoma (GBM), a World Health Organization (WHO) grade IV glioma, is one of the most lethal brain tumors, with a poor prognosis and limited treatment options. Temozolomide (TMZ), a first-line chemotherapeutic agent, often proves ineffective due to resistance and toxicity associated wit...

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Bibliografiske detaljer

Principais autores:	Jiabing Li, Xiaorong Feng, Zhaohui Liu, Yunfang Deng, Zhiming Sun, Bei Chen, Lihui Wu, Xiaolong Wang, Lin Miao, Liyuan Zeng, Lei Hu, Yuming He, Ying Sheng, Yue Liu, Yu Zhao
Format:	Artigo
Sprog:	Inglês
Udgivet:	Nature Publishing Group 2025-08-01
Serier:	Cell Death and Disease
Online adgang:	https://doi.org/10.1038/s41419-025-07969-3
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