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Rational engineering of cholesterol-modified prodrug nanoassemblies for improving the tumor selectivity and safety of mitoxantrone

Mitoxantrone (MTO) is an anthraquinone antitumor drug with potent therapeutic benefits. However, its clinical application is restricted by the severe side effects stemming from poor tumor selectivity. In this study, MTO and cholesterol (CLS) were conjugated via a tumor-selective disulfide bond to ob...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Bowen Zhang, Wenyuan Liu, Jinrui Liu, Minglong Huang, Yaqiao Li, Erwei Zhao, Lurong Zhang, Xianbao Shi, Jin Sun, Zhonggui He, Lingxiao Li, Bingjun Sun
Format: Artigo
Sprache:Inglês
Veröffentlicht: KeAi Communications Co. Ltd. 2026-03-01
Schriftenreihe:Fundamental Research
Schlagworte:
Mitoxantrone
Prodrug nanoassemblies
Cholesterol
Disulfide bonds
Tumor selectivity
Online-Zugang:http://www.sciencedirect.com/science/article/pii/S2667325824002693
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