Rational engineering of cholesterol-modified prodrug nanoassemblies for improving the tumor selectivity and safety of mitoxantrone

Mitoxantrone (MTO) is an anthraquinone antitumor drug with potent therapeutic benefits. However, its clinical application is restricted by the severe side effects stemming from poor tumor selectivity. In this study, MTO and cholesterol (CLS) were conjugated via a tumor-selective disulfide bond to ob...

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Autores principales:	Bowen Zhang, Wenyuan Liu, Jinrui Liu, Minglong Huang, Yaqiao Li, Erwei Zhao, Lurong Zhang, Xianbao Shi, Jin Sun, Zhonggui He, Lingxiao Li, Bingjun Sun
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	KeAi Communications Co. Ltd. 2026-03-01
Colección:	Fundamental Research
Materias:	Mitoxantrone Prodrug nanoassemblies Cholesterol Disulfide bonds Tumor selectivity
Acceso en línea:	http://www.sciencedirect.com/science/article/pii/S2667325824002693
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