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Modulation of gene expression associated with copy number variation identifies key regulatory programs in high-grade serous ovarian carcinoma

High grade serous ovarian carcinoma (HGSOC) is a systemic malignancy characterized by metastatic lesions that spread within the peritoneal cavity. Despite initial sensibility to platinum-based chemotherapy, more than 80% of patients experience a relapse and acquire chemoresistance. From a genomic po...

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Principais autores: Martina Vescio, Lara Paracchini, Luca Beltrame, Maurizio D’Incalci, Sergio Marchini, Linda Pattini
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2023-07-01
coleção:Advances in Cancer Biology - Metastasis
Assuntos:
High-grade serous ovarian carcinoma
Gene expression
Copy number variation
Systems biology
Cancer informatics
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S2667394023000023
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