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Evaluation of quantitative polymerase chain reaction for detecting BRCA1 or BRCA2 copy number loss in high-grade serous ovarian cancer

Abstract Copy number loss (CNL) of tumour suppressors genes, such as BRCA1/2, are frequent but under-researched tumour driver events. Accurate identification of BRCA1/2 CNL has potential therapeutic implications, particularly in high grade serous tubo-ovarian carcinoma (HGSOC), and cost-effective de...

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Principais autores: A. J. Oswald, R. L. Hollis, M. Churchman, I. Croy, A. Ewing, J. P. Thomson, L. J. Stillie, E. Merry, M. Albertella, J. V. Forment, P. Roxburgh, C. A. Semple, C. S. Herrington, C. Gourley
Format: Artigo
Sprog:Inglês
Udgivet: Nature Portfolio 2026-01-01
Serier:Scientific Reports
Fag:
Copy number loss
Quantitative polymerase chain reaction
High grade serous ovarian cancer
BRCA1/2
Online adgang:https://doi.org/10.1038/s41598-025-34516-z
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