Evaluation of quantitative polymerase chain reaction for detecting BRCA1 or BRCA2 copy number loss in high-grade serous ovarian cancer

Abstract Copy number loss (CNL) of tumour suppressors genes, such as BRCA1/2, are frequent but under-researched tumour driver events. Accurate identification of BRCA1/2 CNL has potential therapeutic implications, particularly in high grade serous tubo-ovarian carcinoma (HGSOC), and cost-effective de...

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मुख्य लेखकों:	A. J. Oswald, R. L. Hollis, M. Churchman, I. Croy, A. Ewing, J. P. Thomson, L. J. Stillie, E. Merry, M. Albertella, J. V. Forment, P. Roxburgh, C. A. Semple, C. S. Herrington, C. Gourley
स्वरूप:	Artigo
भाषा:	Inglês
प्रकाशित:	Nature Portfolio 2026-01-01
श्रृंखला:	Scientific Reports
विषय:	Copy number loss Quantitative polymerase chain reaction High grade serous ovarian cancer BRCA1/2
ऑनलाइन पहुंच:	https://doi.org/10.1038/s41598-025-34516-z
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