Modulation of gene expression associated with copy number variation identifies key regulatory programs in high-grade serous ovarian carcinoma

High grade serous ovarian carcinoma (HGSOC) is a systemic malignancy characterized by metastatic lesions that spread within the peritoneal cavity. Despite initial sensibility to platinum-based chemotherapy, more than 80% of patients experience a relapse and acquire chemoresistance. From a genomic po...

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Autors principals:	Martina Vescio, Lara Paracchini, Luca Beltrame, Maurizio D’Incalci, Sergio Marchini, Linda Pattini
Format:	Artigo
Idioma:	Inglês
Publicat:	Elsevier 2023-07-01
Col·lecció:	Advances in Cancer Biology - Metastasis
Matèries:	High-grade serous ovarian carcinoma Gene expression Copy number variation Systems biology Cancer informatics
Accés en línia:	http://www.sciencedirect.com/science/article/pii/S2667394023000023
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