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Engineered self-regulating macrophages for targeted anti-inflammatory drug delivery

Abstract Background Rheumatoid arthritis (RA) is a systemic autoimmune disease characterized by increased levels of inflammation that primarily manifests in the joints. Macrophages act as key drivers for the progression of RA, contributing to the perpetuation of chronic inflammation and dysregulatio...

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Principais autores: Molly Klimak, Amanda Cimino, Kristin L. Lenz, Luke E. Springer, Kelsey H. Collins, Natalia S. Harasymowicz, Nathan Xu, Christine T.N. Pham, Farshid Guilak
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2024-11-01
Serier:Arthritis Research & Therapy
Fag:
Cell therapy
Rheumatoid arthritis
Designer cell
Synthetic biology
Online adgang:https://doi.org/10.1186/s13075-024-03425-3
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