Engineered self-regulating macrophages for targeted anti-inflammatory drug delivery

Abstract Background Rheumatoid arthritis (RA) is a systemic autoimmune disease characterized by increased levels of inflammation that primarily manifests in the joints. Macrophages act as key drivers for the progression of RA, contributing to the perpetuation of chronic inflammation and dysregulatio...

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Principais autores:	Molly Klimak, Amanda Cimino, Kristin L. Lenz, Luke E. Springer, Kelsey H. Collins, Natalia S. Harasymowicz, Nathan Xu, Christine T.N. Pham, Farshid Guilak
Formato:	Artigo
Idioma:	Inglês
Publicado:	BMC 2024-11-01
Series:	Arthritis Research & Therapy
Assuntos:	Cell therapy Rheumatoid arthritis Designer cell Synthetic biology
Acceso en liña:	https://doi.org/10.1186/s13075-024-03425-3
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