A Case for Microtubule Vulnerability in Amyotrophic Lateral Sclerosis: Altered Dynamics During Disease

Amyotrophic lateral sclerosis (ALS) is an aggressive multifactorial disease converging on a common pathology: the degeneration of motor neurons, their axons and neuromuscular synapses. This vulnerability and dysfunction of motor neurons highlights the dependency of these large cells on their intrace...

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Principais autores:	Jayden A Clark, Elise J Yeaman, Catherine A Blizzard, Jyoti A Chuckowree, Tracey C Dickson
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2016-09-01
coleção:	Frontiers in Cellular Neuroscience
Assuntos:	Amyotrophic Lateral Sclerosis Microtubules dynamics axon transport microtubule theraputics
Acesso em linha:	http://journal.frontiersin.org/Journal/10.3389/fncel.2016.00204/full
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