A prolonged pharmacological blockade of type-5 metabotropic glutamate receptors protects cultured spinal cord motor neurons against excitotoxic death

The causes of amyotrophic lateral sclerosis (ALS) are mostly undefined; however, excitotoxic injury and astrogliosis may contribute to motor neuron (MN) degeneration. Group I metabotropic glutamate (mGlu) receptors are over-expressed in reactive astrocytes in ALS, but the functional significance of...

पूर्ण विवरण

ग्रंथसूची विवरण

मुख्य लेखकों:	Simona D'Antoni, Antonio Berretta, Giovanna Seminara, Patrizia Longone, Anna Maria Giuffrida-Stella, Giuseppe Battaglia, Maria A. Sortino, Ferdinando Nicoletti, Maria V. Catania
स्वरूप:	Artigo
भाषा:	Inglês
प्रकाशित:	Elsevier 2011-06-01
श्रृंखला:	Neurobiology of Disease
विषय:	Amyotrophic lateral sclerosis Motor neuron Astrocyte Excitotoxicity Metabotropic glutamate receptor 5 MPEP
ऑनलाइन पहुंच:	http://www.sciencedirect.com/science/article/pii/S0969996111000143
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