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Fluoxetine prevents Aβ1-42-induced toxicity via a paracrine signaling mediated by Transforming-Growth-Factor-β1

Selective reuptake inhibitors (SSRIs), such as fluoxetine and sertraline, increase circulating Transforming-Growth-Factor-β1 (TGF-ß1) levels in depressed patients,and are currently studied for their neuroprotective properties in Alzheimer’s disease (AD). TGF-β1 is an anti-inflammatory cytokine that...

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Principais autores: Filippo Caraci, Fabio Tascedda, Sara Merlo, Cristina Benatti, Simona Federica Spampinato, Antonio Munafò, Gian Marco Leggio, Ferdinando Nicoletti, Nicoletta Brunello, Filippo Drago, Maria Angela Sortino, Agata Copani
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2016-10-01
coleção:Frontiers in Pharmacology
Assuntos:
Depression
Fluoxetine
Neuroprotection
β-Amyloid
Alzheimer’s disease
Antidepressants
Acesso em linha:http://journal.frontiersin.org/Journal/10.3389/fphar.2016.00389/full
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