Tumor cells promote immunosuppression in ovarian cancer via a positive feedback loop with MDSCs through the SAA1–IL-1β axis

Abstract Background Immune tolerance in epithelial ovarian cancer (EOC) enables cancer cells to evade immune surveillance. Myeloid-derived suppressor cells (MDSCs), as crucial immunosuppressive regulators, shape the tumor microenvironment and contribute to resistance against immunotherapy. However,...

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Autors principals:	Haoran Hu, Meiqin Yang, Baoyou Huang, Jianyi Ding, Yashi Zhu, Xinxin Xu, Bo Yin, Huijuan Zhou, Tiefeng Huang, Mengjie Li, Yifan Kou, Zilale Rahim, Ang Li, Wei Wang, Lingfei Han
Format:	Artigo
Idioma:	Inglês
Publicat:	BMC 2025-09-01
Col·lecció:	Journal of Experimental & Clinical Cancer Research
Matèries:	SAA1 MDSCs IL-1β Toll-like receptor Immunosuppressive microenvironment
Accés en línia:	https://doi.org/10.1186/s13046-025-03536-y
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