Exosomal CMTM4 Induces Immunosuppressive Macrophages to Promote Ovarian Cancer Progression and Attenuate Anti‐PD‐1 Immunotherapy

Abstract Exosomes shape the tumor microenvironment (TME) by modulating tumor‐associated macrophages (TAMs) and promoting ovarian cancer (OC) progression. This study reveals that exosomal CKLF Like MARVEL Transmembrane Domain Containing 4 (CMTM4) enhances OC malignancy and orchestrates immune evasion...

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Autori principali:	Bo Yin, Jianyi Ding, Jie Liu, Haoran Hu, Yashi Zhu, Meiqin Yang, Huijuan Zhou, Baoyou Huang, Tiefeng Huang, Mengjie Li, Yinyan He, Ang Li, Lingfei Han
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Wiley 2025-08-01
Serie:	Advanced Science
Soggetti:	CMTM4 exosomal CMTM4 macrophage polarization ovarian cancer tumor‐associated macrophages
Accesso online:	https://doi.org/10.1002/advs.202504436
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