Enzymatic Transglycosylation Features in Synthesis of 8-Aza-7-Deazapurine Fleximer Nucleosides by Recombinant <i>E. coli</i> PNP: Synthesis and Structure Determination of Minor Products

Enzymatic transglycosylation of the fleximer base 4-(4-aminopyridine-3-yl)-1H-pyrazole using recombinant <i>E. coli</i> purine nucleoside phosphorylase (PNP) resulted in the formation of “non-typical” minor products of the reaction. In addition to “typical” N1-pyrazole nucleosides, a 4-imino-pyridin...

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Principais autores:	Barbara Z. Eletskaya, Anton F. Mironov, Ilya V. Fateev, Maria Ya. Berzina, Konstantin V. Antonov, Olga S. Smirnova, Alexandra B. Zatsepina, Alexandra O. Arnautova, Yulia A. Abramchik, Alexander S. Paramonov, Alexey L. Kayushin, Anastasia L. Khandazhinskaya, Elena S. Matyugina, Sergey N. Kochetkov, Anatoly I. Miroshnikov, Igor A. Mikhailopulo, Roman S. Esipov, Irina D. Konstantinova
Formato:	Artigo
Idioma:	Inglês
Publicado em:	MDPI AG 2024-07-01
coleção:	Biomolecules
Assuntos:	fleximer base recombinant <i>E. coli</i> PNP catalytic site molecular modeling
Acesso em linha:	https://www.mdpi.com/2218-273X/14/7/798
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