Enzymatic Transglycosylation Features in Synthesis of 8-Aza-7-Deazapurine Fleximer Nucleosides by Recombinant <i>E. coli</i> PNP: Synthesis and Structure Determination of Minor Products

Enzymatic transglycosylation of the fleximer base 4-(4-aminopyridine-3-yl)-1H-pyrazole using recombinant <i>E. coli</i> purine nucleoside phosphorylase (PNP) resulted in the formation of “non-typical” minor products of the reaction. In addition to “typical” N1-pyrazole nucleosides, a 4-imino-pyridin...

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Hauptverfasser:	Barbara Z. Eletskaya, Anton F. Mironov, Ilya V. Fateev, Maria Ya. Berzina, Konstantin V. Antonov, Olga S. Smirnova, Alexandra B. Zatsepina, Alexandra O. Arnautova, Yulia A. Abramchik, Alexander S. Paramonov, Alexey L. Kayushin, Anastasia L. Khandazhinskaya, Elena S. Matyugina, Sergey N. Kochetkov, Anatoly I. Miroshnikov, Igor A. Mikhailopulo, Roman S. Esipov, Irina D. Konstantinova
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	MDPI AG 2024-07-01
Schriftenreihe:	Biomolecules
Schlagworte:	fleximer base recombinant <i>E. coli</i> PNP catalytic site molecular modeling
Online-Zugang:	https://www.mdpi.com/2218-273X/14/7/798
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