Impact of busulfan exposure stratification on transplant outcomes and immune reconstitution in children with severe aplastic anemia

BackgroundSevere aplastic anemia (SAA) is a life-threatening bone marrow failure disorder. Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is an established curative treatment for pediatric patients with SAA. Busulfan, a key component of conditioning regimens, has a narrow therapeutic...

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Váldodahkkit:	Yanxiao Li, Xiaoying Zhai, Qianqian Zhang, Yile Zhao, Chenhong Jia
Materiálatiipa:	Artigo
Giella:	Inglês
Almmustuhtton:	Frontiers Media S.A. 2026-09-01
Ráidu:	Frontiers in Pharmacology
Fáttát:	allogeneic hematopoietic stem cell transplantation busulfan children immune reconstitution pharmacokinetics severe aplastic anemia
Liŋkkat:	https://www.frontiersin.org/articles/10.3389/fphar.2026.1897156/full
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