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Impact of busulfan exposure stratification on transplant outcomes and immune reconstitution in children with severe aplastic anemia

BackgroundSevere aplastic anemia (SAA) is a life-threatening bone marrow failure disorder. Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is an established curative treatment for pediatric patients with SAA. Busulfan, a key component of conditioning regimens, has a narrow therapeutic...

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Principais autores: Yanxiao Li, Xiaoying Zhai, Qianqian Zhang, Yile Zhao, Chenhong Jia
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2026-09-01
coleção:Frontiers in Pharmacology
Assuntos:
allogeneic hematopoietic stem cell transplantation
busulfan
children
immune reconstitution
pharmacokinetics
severe aplastic anemia
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fphar.2026.1897156/full
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