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Mechanistic models of asymmetric hand-over-hand translocation and nucleosome navigation by CMG helicase

Abstract Faithful replication of eukaryotic chromatin requires the CMG helicase to translocate directionally along single-stranded DNA (ssDNA) while unwinding double-stranded DNA (dsDNA) and navigating nucleosomes. However, the mechanism by which CMG achieves processive translocation and deals with...

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主要な著者: Fritz Nagae, Yutaka Murata, Masataka Yamauchi, Shoji Takada, Tsuyoshi Terakawa
フォーマット: Artigo
言語:Inglês
出版事項: Nature Portfolio 2025-11-01
シリーズ:Nature Communications
オンライン・アクセス:https://doi.org/10.1038/s41467-025-65232-x
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