3-(((1<i>S</i>,3<i>S</i>)-3-((<i>R</i>)-Hydroxy(4-(trifluoromethyl)phenyl)methyl)-4-oxocyclohexyl)methyl)pentane-2,4-dione: Design and Synthesis of New Stereopure Multi-Target Antidiabetic Agent

The chiral drug candidates have more effective binding affinities for their specific protein or receptor site for the onset of pharmacological action. Achieving all carbon stereopure compounds is not trivial in chemical synthesis. However, with the development of asymmetric organocatalysis, the synt...

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Principais autores:	Abdul Sadiq, Mater H. Mahnashi, Umer Rashid, Muhammad Saeed Jan, Mohammed Abdulrahman Alshahrani, Mohammed A. Huneif
Formato:	Artigo
Idioma:	Inglês
Publicado em:	MDPI AG 2022-05-01
coleção:	Molecules
Assuntos:	chiral synthesis antidiabetic molecular docking α-glucosidase α-amylase PTP1B and DPPH
Acesso em linha:	https://www.mdpi.com/1420-3049/27/10/3265
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