Helicobacter pylori Modulates Heptose Metabolite Biosynthesis and Heptose-Dependent Innate Immune Host Cell Activation by Multiple Mechanisms

ABSTRACT Heptose metabolites including ADP-d-glycero-β-d-manno-heptose (ADP-heptose) are involved in bacterial lipopolysaccharide and cell envelope biosynthesis. Recently, heptoses were also identified to have potent proinflammatory activity on human cells as novel microbe-associated molecular patte...

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Autori principali:	Martina Hauke, Felix Metz, Johanna Rapp, Larissa Faass, Simon H. Bats, Sandra Radziej, Hannes Link, Wolfgang Eisenreich, Christine Josenhans
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology 2023-06-01
Serie:	Microbiology Spectrum
Soggetti:	ADP-heptose ALPK1-TIFA Helicobacter pylori mass spectrometry NMR bacterial metabolites
Accesso online:	https://journals.asm.org/doi/10.1128/spectrum.03132-22
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