Helicobacter pylori GmhB enzyme involved in ADP-heptose biosynthesis pathway is essential for lipopolysaccharide biosynthesis and bacterial virulence

Helicobacter pylori infection is linked to serious gastric-related diseases including gastric cancer. However, current therapies for treating H. pylori infection are challenged by the increased antibiotic resistance of H. pylori. Therefore, it is in an urgent need to identify novel targets for drug...

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Autori principali:	Sue-Fen Chiu, Kai-Wen Teng, Po-Chuan Wang, Hsin-Yu Chung, Chun-Jen Wang, Hui-Chun Cheng, Mou-Chieh Kao
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Taylor & Francis Group 2021-12-01
Serie:	Virulence
Soggetti:	helicobacter pylori d-glycero-d-manno-heptose-1, 7-bisphosphate phosphatase (gmhb) heptose biosynthesis lipopolysaccharide outer membrane vesicle bacterial pathogenesis drug target virulence factor enzyme kinetics
Accesso online:	http://dx.doi.org/10.1080/21505594.2021.1938449
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