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Alpha-synuclein oligomer-selective antibodies reduce intracellular accumulation and mitochondrial impairment in alpha-synuclein exposed astrocytes

Abstract Background Due to its neurotoxic properties, oligomeric alpha-synuclein (α-syn) has been suggested as an attractive target for passive immunization against Parkinson’s disease (PD). In mouse models of PD, antibody treatment has been shown to lower the levels of pathogenic α-syn species, inc...

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Gespeichert in:
Hauptverfasser: Gabriel Gustafsson, Veronica Lindström, Jinar Rostami, Eva Nordström, Lars Lannfelt, Joakim Bergström, Martin Ingelsson, Anna Erlandsson
Format: Artigo
Sprache:Inglês
Veröffentlicht: BMC 2017-12-01
Schriftenreihe:Journal of Neuroinflammation
Schlagworte:
α-synuclein oligomers
Astrocytes
Antibodies
Mitochondria
Lysosomal degradation
Parkinson’s disease
Online-Zugang:http://link.springer.com/article/10.1186/s12974-017-1018-z
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