Alpha-synuclein oligomer-selective antibodies reduce intracellular accumulation and mitochondrial impairment in alpha-synuclein exposed astrocytes

Abstract Background Due to its neurotoxic properties, oligomeric alpha-synuclein (α-syn) has been suggested as an attractive target for passive immunization against Parkinson’s disease (PD). In mouse models of PD, antibody treatment has been shown to lower the levels of pathogenic α-syn species, inc...

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Hlavní autoři:	Gabriel Gustafsson, Veronica Lindström, Jinar Rostami, Eva Nordström, Lars Lannfelt, Joakim Bergström, Martin Ingelsson, Anna Erlandsson
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	BMC 2017-12-01
Edice:	Journal of Neuroinflammation
Témata:	α-synuclein oligomers Astrocytes Antibodies Mitochondria Lysosomal degradation Parkinson’s disease
On-line přístup:	http://link.springer.com/article/10.1186/s12974-017-1018-z
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