CircRAPGEF5 acts as a modulator of RAS/RAF/MEK/ERK signaling during colorectal carcinogenesis

Mutations in oncogenes such as KRAS, NRAS and BRAF promote the growth and survival of tumors, while excessive RAS/RAF/MEK/ERK activation inhibits tumor growth. In this study we examined the precise regulatory machinery that maintains a moderate RAS/RAF/MEK/ERK pathway activation during CRC. Here, us...

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Principais autores:	Zhipeng Yin, Hao Li, Heng Zhao, Lutterodt Bentum-Ennin, Yang Xia, Zaibiao Wang, Wanglai Hu, Hao Gu, Shangxin Zhang, Guangyun Li
Format:	Artigo
Jezik:	Inglês
Izdano:	Elsevier 2024-08-01
Serija:	Heliyon
Teme:	CircRAPGEF5 Colorectal cancer Apoptosis RAS/RAF/MEK/ERK signaling
Online dostop:	http://www.sciencedirect.com/science/article/pii/S2405844024121640
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