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CircRAPGEF5 acts as a modulator of RAS/RAF/MEK/ERK signaling during colorectal carcinogenesis

Mutations in oncogenes such as KRAS, NRAS and BRAF promote the growth and survival of tumors, while excessive RAS/RAF/MEK/ERK activation inhibits tumor growth. In this study we examined the precise regulatory machinery that maintains a moderate RAS/RAF/MEK/ERK pathway activation during CRC. Here, us...

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Autores principales: Zhipeng Yin, Hao Li, Heng Zhao, Lutterodt Bentum-Ennin, Yang Xia, Zaibiao Wang, Wanglai Hu, Hao Gu, Shangxin Zhang, Guangyun Li
Formato: Artigo
Lenguaje:Inglês
Publicado: Elsevier 2024-08-01
Colección:Heliyon
Materias:
CircRAPGEF5
Colorectal cancer
Apoptosis
RAS/RAF/MEK/ERK signaling
Acceso en línea:http://www.sciencedirect.com/science/article/pii/S2405844024121640
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