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Geniposide alleviates lipopolysaccharide-caused apoptosis of murine kidney podocytes by activating Ras/Raf/MEK/ERK-mediated cell autophagy

Proteinuria is one of the most important clinical features of nephrotic syndrome (NS). Injury of podocyte has been proved to contribute to the occurrence of proteinuria. This study explored the effects of geniposide (GEN) on lipopolysaccharide (LPS)-caused murine kidney podocyte MPC5 apoptosis and a...

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Principais autores: Xia Li, Aijing Ma, Kun Liu
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis Group 2019-12-01
Serier:Artificial Cells, Nanomedicine, and Biotechnology
Fag:
Nephrotic syndrome
podocytes
geniposide
cell apoptosis
cell autophagy
Ras/Raf/MEK/ERK pathway
Online adgang:https://www.tandfonline.com/doi/10.1080/21691401.2019.1601630
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