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Integrated multi-omics reveals glycolytic gene signatures of lung adenocarcinoma brain metastasis and the impact of Rac2 lactylation on immunosuppressive microenvironment

Abstract Purpose Tumor Metabolic Behavior modulates the immunosuppressive microenvironment through multiple pathways, thereby compromising anti-tumor immune responses. To date, there have been limited studies assessing the role of metabolic plasticity or immunometabolism in the tumor microenvironmen...

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Váldodahkkit: Yali Yi, Wenjie Xu, Houjian Yu, Yuxi Luo, Fujuan Zeng, Daya Luo, Zhimin Zeng, Le Xiong, Long Huang, Jing Cai, Anwen Liu
Materiálatiipa: Artigo
Giella:Inglês
Almmustuhtton: BMC 2025-10-01
Ráidu:Journal of Translational Medicine
Fáttát:
Liŋkkat:https://doi.org/10.1186/s12967-025-07207-6
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