Random Insertion of mCherry Into VP3 Domain of Adeno-associated Virus Yields Fluorescent Capsids With no Loss of Infectivity

Adeno-associated virus (AAV)-derived vectors are promising gene delivery systems, and a number of design strategies have been pursued to improve their performance. For example, genetic insertion of proteins into the capsid may be used to achieve vector retargeting, reduced immunogenicity, or to trac...

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主要な著者:	Justin Judd, Fang Wei, Peter Q Nguyen, Lawrence J Tartaglia, Mavis Agbandje-McKenna, Jonathan J Silberg, Junghae Suh
フォーマット:	Artigo
言語:	Inglês
出版事項:	Elsevier 2012-01-01
シリーズ:	Molecular Therapy: Nucleic Acids
主題:	AAV directed evolution random domain insertion
オンライン･アクセス:	http://www.sciencedirect.com/science/article/pii/S2162253116301111
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