Quantifying DNA strand breaks from targeted alpha emitters 225Ac and 227Th via Geant4-DNA: implications for RBE and cell survival

Abstract Background Targeted alpha therapy (TAT) utilizing high-LET alpha particles from radionuclides like 225Ac and 227Th shows promise in cancer treatment due to their ability to induce dense, localized DNA damage. This study uses the Geant4-DNA Monte Carlo toolkit to simulate DNA damage and eval...

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Номзүйн дэлгэрэнгүй

Үндсэн зохиолчид:	Samaneh Zolghadri, Payman Rafiepour, Hassan Yousefnia
Формат:	Artigo
Хэл сонгох:	Inglês
Хэвлэсэн:	SpringerOpen 2025-10-01
Цуврал:	EJNMMI Physics
Нөхцлүүд:	Targeted alpha therapy DNA damage 225Ac 227Th GEANT4-DNA Relative biological effectiveness
Онлайн хандалт:	https://doi.org/10.1186/s40658-025-00805-9
Шошгууд:	Шошго нэмэх Шошго байхгүй, Энэхүү баримтыг шошголох эхний хүн болох!