Quantifying DNA strand breaks from targeted alpha emitters 225Ac and 227Th via Geant4-DNA: implications for RBE and cell survival
Abstract Background Targeted alpha therapy (TAT) utilizing high-LET alpha particles from radionuclides like 225Ac and 227Th shows promise in cancer treatment due to their ability to induce dense, localized DNA damage. This study uses the Geant4-DNA Monte Carlo toolkit to simulate DNA damage and eval...
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| Автори: | , , |
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| Формат: | Artigo |
| Мова: | Inglês |
| Опубліковано: |
SpringerOpen
2025-10-01
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| Серія: | EJNMMI Physics |
| Предмети: | |
| Онлайн доступ: | https://doi.org/10.1186/s40658-025-00805-9 |
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