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Substrate Stiffness Modulates Hypertrophic Chondrocyte Reversion and Chondrogenic Phenotype Restoration

The stiffness of the extracellular matrix (ECM) plays a pivotal role in the progression of osteoarthritis (OA), particularly by promoting hypertrophic differentiation of chondrocytes, which hinders cartilage regeneration and accelerates pathological ossification. This study aimed to investigate how...

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Autori principali: Da-Long Dong, Guang-Zhen Jin
Natura: Artigo
Lingua:Inglês
Pubblicazione: MDPI AG 2025-08-01
Serie:Cells
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Accesso online:https://www.mdpi.com/2073-4409/14/16/1291
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