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Inhibition of cyclooxygenase-2 impacts chondrocyte hypertrophic differentiation during endochondral ossification

Skeletogenesis and bone fracture healing involve endochondral ossification, a process during which cartilaginous primordia are gradually replaced by bone tissue. In line with a role for cyclooxygenase-2 (COX-2) in the endochondral ossification process, non-steroidal anti-inflammatory drugs (NSAIDs)...

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Main Authors: TJM Welting, MMJ Caron, PJ Emans, MPF Janssen, K Sanen, MME Coolsen, L Voss, DAM Surtel, A Cremers, JW Voncken, LW van Rhijn
Format: Artigo
Language:Inglês
Published: Forum Multimedia Publishing LLC 2011-12-01
Series:European Cells & Materials
Subjects:
Stem cells
chondrogenesis
growth factors
COX-2 inhibition
chondrocyte hypertrophy
endochondral ossification
Online Access:http://www.ecmjournal.org/journal/papers/vol022/pdf/v022a31.pdf
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