Structural asymmetry governs the assembly and GTPase activity of McrBC restriction complexes
The bacterial defense system McrBC is a two-component motor-driven nuclease complex that cleaves foreign DNA. Here, the authors present the structures of the GTP-specific AAA + motor protein McrB and two McrBC complexes and discuss the molecular mechanism of how McrC binding stimulates McrB GTP hydr...
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| Autori principali: | , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Nature Portfolio
2020-11-01
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| Serie: | Nature Communications |
| Accesso online: | https://doi.org/10.1038/s41467-020-19735-4 |
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