Computational Study on Selective PDE9 Inhibitors on PDE9-Mg/Mg, PDE9-Zn/Mg, and PDE9-Zn/Zn Systems

PDE9 inhibitors have been studied to validate their potential to treat diabetes, neurodegenerative disorders, cardiovascular diseases, and erectile dysfunction. In this report, we have selected highly potent previously reported selective PDE9 inhibitors BAY73-6691R, BAY73-6691S, 28r, 28s, 3r, 3s, PF...

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Autors principals:	Dakshinamurthy Sivakumar, Sathishkumar Mudedla, Seonghun Jang, Hyunjun Kim, Hyunjin Park, Yonwon Choi, Joongyo Oh, Sangwook Wu
Format:	Artigo
Idioma:	Inglês
Publicat:	MDPI AG 2021-05-01
Col·lecció:	Biomolecules
Matèries:	selective inhibitors PDE9 molecular dynamics metal complexes BAY73-6691
Accés en línia:	https://www.mdpi.com/2218-273X/11/5/709
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