Isoform-specific and signaling-dependent propagation of acute myeloid leukemia by Wilms tumor 1

Summary: Acute myeloid leukemia (AML) is caused by recurrent mutations in members of the gene regulatory and signaling machinery that control hematopoietic progenitor cell growth and differentiation. Here, we show that the transcription factor WT1 forms a major node in the rewired mutation-specific...

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Hauptverfasser:	Sandeep Potluri, Salam A. Assi, Paulynn S. Chin, Dan J.L. Coleman, Anna Pickin, Shogo Moriya, Naohiko Seki, Olaf Heidenreich, Peter N. Cockerill, Constanze Bonifer
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Elsevier 2021-04-01
Schriftenreihe:	Cell Reports
Schlagworte:	acute myeloid leukemia Wilms tumour 1 t(8;21) AML FLT3-ITD AML gene regulatory networks chromatin
Online-Zugang:	http://www.sciencedirect.com/science/article/pii/S2211124721003247
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