Expression of RUNX1-ETO Rapidly Alters the Chromatin Landscape and Growth of Early Human Myeloid Precursor Cells

Summary: Acute myeloid leukemia (AML) is a hematopoietic malignancy caused by recurrent mutations in genes encoding transcriptional, chromatin, and/or signaling regulators. The t(8;21) translocation generates the aberrant transcription factor RUNX1-ETO (RUNX1-RUNX1T1), which by itself is insufficien...

ver descrição completa

Detalhes bibliográficos

Principais autores:	Monica Nafria, Peter Keane, Elizabeth S. Ng, Edouard G. Stanley, Andrew G. Elefanty, Constanze Bonifer
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2020-05-01
coleção:	Cell Reports
Assuntos:	Acute Myeloid Leukemia (AML) RUNX1-ETO chromatin human ES cell differentiation myelopoiesis single cell RNA-Seq
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S2211124720306446
Tags:	Adicionar Tag Sem tags, seja o primeiro a adicionar uma tag!