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Cell-Based Luciferase Assay for Testing SARS-CoV-2 3CL Protease Inhibitors

A cell-based screening system for viral protease inhibitors was developed using firefly luciferase fragment complementation and validated on the SARS-CoV-2 3CLpro model. The optimal luciferase variant incorporating the VLQSGF proteolytic site (Luc III) retained 88% of its native activity. A critical...

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Principais autores: Dmitry N. Shcherbakov, Ekaterina D. Mordvinova, Vadim O. Trufanov, Natalia V. Volkova, Yulia V. Meshkova, Maria K. Marenina, Anna V. Zaykovskaya, Ekaterina A. Volosnikova, Sophia S. Borisevich, Svetlana V. Belenkaya
Formato: Artigo
Idioma:Inglês
Publicado: MDPI AG 2026-04-01
Series:Biosensors
Assuntos:
SARS-CoV-2
3CLpro
high-throughput screening
viral proteases
luciferase
antiviral inhibitor
Acceso en liña:https://www.mdpi.com/2079-6374/16/5/253
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