Cell-Based Luciferase Assay for Testing SARS-CoV-2 3CL Protease Inhibitors
A cell-based screening system for viral protease inhibitors was developed using firefly luciferase fragment complementation and validated on the SARS-CoV-2 3CLpro model. The optimal luciferase variant incorporating the VLQSGF proteolytic site (Luc III) retained 88% of its native activity. A critical...
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| Autori principali: | , , , , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
MDPI AG
2026-04-01
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| Serie: | Biosensors |
| Soggetti: | |
| Accesso online: | https://www.mdpi.com/2079-6374/16/5/253 |
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