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Cell-Based Luciferase Assay for Testing SARS-CoV-2 3CL Protease Inhibitors

A cell-based screening system for viral protease inhibitors was developed using firefly luciferase fragment complementation and validated on the SARS-CoV-2 3CLpro model. The optimal luciferase variant incorporating the VLQSGF proteolytic site (Luc III) retained 88% of its native activity. A critical...

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Principais autores: Dmitry N. Shcherbakov, Ekaterina D. Mordvinova, Vadim O. Trufanov, Natalia V. Volkova, Yulia V. Meshkova, Maria K. Marenina, Anna V. Zaykovskaya, Ekaterina A. Volosnikova, Sophia S. Borisevich, Svetlana V. Belenkaya
פורמט: Artigo
שפה:Inglês
יצא לאור: MDPI AG 2026-04-01
סדרה:Biosensors
נושאים:
SARS-CoV-2
3CLpro
high-throughput screening
viral proteases
luciferase
antiviral inhibitor
גישה מקוונת:https://www.mdpi.com/2079-6374/16/5/253
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