Genetic ablation of TRPC6 facilitated age-dependent atherosclerosis progression in an ApoE-/- mouse model

BackgroundTRPC6 channels are expressed in endothelial cells, smooth muscle cells, and macrophages within the atherosclerotic segments of conduit blood vessels. Genetic or pharmacological inactivation of TRPC6 was variably associated with the development of atherosclerosis, a risk factor for myocardi...

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Egile Nagusiak:	Isaac S. Demaree, Sreepadaarchana Munjuluri, Saketh Boyapalli, Regan E. Beaty, Dru A. Wilkerson, Sruthilatha Sakthi Velavan, Fletcher A. White, Alexander G. Obukhov
Formatua:	Artigo
Hizkuntza:	Inglês
Argitaratua:	Frontiers Media S.A. 2026-07-01
Saila:	Frontiers in Physiology
Gaiak:	atherosclerosis calcification cation channels fibrous cap TRPC6
Sarrera elektronikoa:	https://www.frontiersin.org/articles/10.3389/fphys.2026.1884753/full
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