Genetic ablation of TRPC6 facilitated age-dependent atherosclerosis progression in an ApoE-/- mouse model

BackgroundTRPC6 channels are expressed in endothelial cells, smooth muscle cells, and macrophages within the atherosclerotic segments of conduit blood vessels. Genetic or pharmacological inactivation of TRPC6 was variably associated with the development of atherosclerosis, a risk factor for myocardi...

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Номзүйн дэлгэрэнгүй

Үндсэн зохиолчид:	Isaac S. Demaree, Sreepadaarchana Munjuluri, Saketh Boyapalli, Regan E. Beaty, Dru A. Wilkerson, Sruthilatha Sakthi Velavan, Fletcher A. White, Alexander G. Obukhov
Формат:	Artigo
Хэл сонгох:	Inglês
Хэвлэсэн:	Frontiers Media S.A. 2026-07-01
Цуврал:	Frontiers in Physiology
Нөхцлүүд:	atherosclerosis calcification cation channels fibrous cap TRPC6
Онлайн хандалт:	https://www.frontiersin.org/articles/10.3389/fphys.2026.1884753/full
Шошгууд:	Шошго нэмэх Шошго байхгүй, Энэхүү баримтыг шошголох эхний хүн болох!