Genetic ablation of TRPC6 facilitated age-dependent atherosclerosis progression in an ApoE-/- mouse model

BackgroundTRPC6 channels are expressed in endothelial cells, smooth muscle cells, and macrophages within the atherosclerotic segments of conduit blood vessels. Genetic or pharmacological inactivation of TRPC6 was variably associated with the development of atherosclerosis, a risk factor for myocardi...

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主要な著者:	Isaac S. Demaree, Sreepadaarchana Munjuluri, Saketh Boyapalli, Regan E. Beaty, Dru A. Wilkerson, Sruthilatha Sakthi Velavan, Fletcher A. White, Alexander G. Obukhov
フォーマット:	Artigo
言語:	Inglês
出版事項:	Frontiers Media S.A. 2026-07-01
シリーズ:	Frontiers in Physiology
主題:	atherosclerosis calcification cation channels fibrous cap TRPC6
オンライン･アクセス:	https://www.frontiersin.org/articles/10.3389/fphys.2026.1884753/full
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