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Synthesis of Microwave Functionalized, Nanostructured Polylactic Co-Glycolic Acid (<i>nf</i>PLGA) for Incorporation into Hydrophobic Dexamethasone to Enhance Dissolution

The low solubility and slow dissolution of hydrophobic drugs is a major challenge for the pharmaceutical industry. In this paper, we present the synthesis of surface-functionalized poly(lactic-co-glycolic acid) (PLGA) nanoparticles for incorporation into corticosteroid dexamethasone to improve its i...

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Main Authors: Mohammad Saiful Islam, Somenath Mitra
Format: Artigo
Language:Inglês
Published: MDPI AG 2023-03-01
Series:Nanomaterials
Subjects:
hydrophobic drug
FDA polymer
microwave functionalization
dexamethasone
in vitro dissolution
absorption bioavailability
Online Access:https://www.mdpi.com/2079-4991/13/5/943
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