Structural dynamics of the E6AP/UBE3A-E6-p53 enzyme-substrate complex

Oncoprotein E6 facilitates the E6AP-catalyzed ubiquitination of p53. Here, the authors study the structural basis of this process by qualitative and quantitative cross-linking mass spectrometry, providing insights into E6AP-E6-p53 complex assembly and the conformational dynamics that enable p53 ubiq...

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Váldodahkkit:	Carolin Sailer, Fabian Offensperger, Alexandra Julier, Kai-Michael Kammer, Ryan Walker-Gray, Matthew G. Gold, Martin Scheffner, Florian Stengel
Materiálatiipa:	Artigo
Giella:	Inglês
Almmustuhtton:	Nature Portfolio 2018-10-01
Ráidu:	Nature Communications
Liŋkkat:	https://doi.org/10.1038/s41467-018-06953-0
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