Reconstitution of p53-ubiquitinylation reactions from purified components: the role of human ubiquitin-conjugating enzyme UBC4 and E6-associated protein (E6AP).

The E6 protein of the high-risk human papillomaviruses inactivates the tumor suppressor protein p53 by stimulating its ubiquitinylation and subsequent degradation. Ubiquitinylation is a multistep process involving a ubiquitin-activating enzyme, one of many distinct ubiquitin-conjugating enzymes, and...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Rolfe, M, Beer-Romero, P, Glass, S, Eckstein, J, Berdo, I, Theodoras, A, Pagano, M, Draetta, G
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1995
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC42146/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7724550/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.92.8.3264
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