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Depletion of nuclear import protein karyopherin alpha 7 (KPNA7) induces mitotic defects and deformation of nuclei in cancer cells

Abstract Background Nucleocytoplasmic transport is a tightly regulated process carried out by specific transport machinery, the defects of which may lead to a number of diseases including cancer. Karyopherin alpha 7 (KPNA7), the newest member of the karyopherin alpha nuclear importer family, is expr...

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Principais autores: Elisa M. Vuorinen, Nina K. Rajala, Teemu O. Ihalainen, Anne Kallioniemi
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2018-03-01
Serier:BMC Cancer
Fag:
KPNA7
Importin alpha 8
Nuclear transfer
Nuclear morphology
Cell proliferation
Mitosis
Online adgang:http://link.springer.com/article/10.1186/s12885-018-4261-5
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