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Vaccination with Live or Heat-Killed Aspergillus fumigatus ΔsglA Conidia Fully Protects Immunocompromised Mice from Invasive Aspergillosis

ABSTRACT Aspergillus fumigatus causes invasive aspergillosis (IA) in immunocompromised patients, resulting in high mortality rates. Currently, no vaccine formulations to promote immune protection in at-risk individuals have been developed. In this work, we deleted the sterylglucosidase-encoding gene...

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Principais autores: Caroline Mota Fernandes, Tyler G. Normile, Joao Henrique Tadini Marilhano Fabri, Veronica Soares Brauer, Glauber R. de S. Araújo, Susana Frases, Leonardo Nimrichter, Iran Malavazi, Maurizio Del Poeta
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2022-10-01
Serier:mBio
Fag:
fungal infection
Aspergillus
invasive aspergillosis
vaccine
sterylglucosides
immunocompromised host
Online adgang:https://journals.asm.org/doi/10.1128/mbio.02328-22
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